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Archive for October, 2013

Alternative to Globe Valves in Your Pharmaceutical Plant

A biopharmaceutical plant in the U. S. was operating a cold/chilled glycol (CG) system to cool approximately 50 process vessels, mainly jacketed tanks (250 – 3500 L), and several heat exchangers to produce its products. The plant was approximately 18 years old and circulated propylene glycol (40%) and water (60%) as the heat transfer medium. Chillers in the basement generated 28°F (-2°C)cold glycol which was then circulated by three constant-speed centrifugal pumps to the distribution network. System differential pressure control was achieved with a bypass valve that short-circuited the CG supply to the return side during periods of low demand.

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